A client with multiple sclerosis is treated with baclofen. What outcome indicates a favorable therapeutic response?

A client with multiple sclerosis is treated with baclofen. What outcome indicates a favorable therapeutic response?

• A. Decreased muscle spasms
• B. Increased appetite
• C. Weight gain
• D. Drowsiness

Answer: (A)

Reducing spasticity is the goal of baclofen in multiple sclerosis. Baclofen works by activating GABA-B receptors in the spinal cord to dampen motor reflexes and lower muscle tone, so improvement shows up as fewer and less intense muscle spasms, allowing better movement and function. Appetite changes or weight gain are not expected benefits of this drug, and drowsiness is a common side effect rather than a sign of therapeutic success. Therefore, a decrease in muscle spasms best indicates a favorable response.

Reducing spasticity is the goal of baclofen in multiple sclerosis. Baclofen works by activating GABA-B receptors in the spinal cord to dampen motor reflexes and lower muscle tone, so improvement shows up as fewer and less intense muscle spasms, allowing better movement and function. Appetite changes or weight gain are not expected benefits of this drug, and drowsiness is a common side effect rather than a sign of therapeutic success. Therefore, a decrease in muscle spasms best indicates a favorable response.