What is the maintenance dosing frequency of oral dantrolene for spasticity?

What is the maintenance dosing frequency of oral dantrolene for spasticity?

• A. 25 mg once daily
• B. 50 mg twice daily
• C. 100 mg twice daily
• D. 200 mg twice daily

Answer: (C)

Dantrolene maintenance dosing aims to keep steady drug levels to continuously reduce spasticity without large peaks that can increase side effects. In oral therapy, a common maintenance regimen is 100 mg per dose taken twice daily, providing about 200 mg per day. This dosing schedule helps maintain consistent control of muscle tone while balancing tolerability and safety, since higher peaks can worsen sedation and long-term use requires liver function monitoring. Other options either underrepresent or overstate the typical per-dose amount or frequency, making them less aligned with standard maintenance practice.

Dantrolene maintenance dosing aims to keep steady drug levels to continuously reduce spasticity without large peaks that can increase side effects. In oral therapy, a common maintenance regimen is 100 mg per dose taken twice daily, providing about 200 mg per day. This dosing schedule helps maintain consistent control of muscle tone while balancing tolerability and safety, since higher peaks can worsen sedation and long-term use requires liver function monitoring. Other options either underrepresent or overstate the typical per-dose amount or frequency, making them less aligned with standard maintenance practice.